122 Chapter 10 Figure 1. A: Example of partially collapsed peripheral lung in which alveoli are covered with epithelial tumor cells. Classified as non-invasive, adenocarcinoma in situ (AIS). Centrally a pulmonary artery with clusters and isolated tumor cells. Hematoxylin & Eosin (H&E) 200x, B: Same area as in figure A. Cytokeratin 7 (CK7) immunohistochemical stain, 200x. C: Example of another pulmonary artery with clusters of tumor cells (blue arrow heads), alveolar macrophages (blue arrows) and some erythrocytes. H&E stain, 400x. D: same artery as in figure C. CK7 immunohistochemical stain, 400x. Validation study Clinicopathological characteristics In the validation study a total of 70 tumor slides of 70 patients were analyzed. The clinicopathological characteristics of the patients are presented in table 2. The histological diagnosis was invasive carcinoma for 60 tumors. A total of 10 patients were classified as non-invasive/ AIS (14.3%). Table 2. Clinicopathological variables in the two validation cohorts. Milan OLVG Total Number of patients 35 35 70 Age (mean+SD) 67.2 + 9.9 61.5 + 7.6 64.4 + 9.2 Sex (%) Male 25 (71.4%) 12 (34.3%) 37 (52.9%) Female 10 (28.6%) 23 (65.7%) 33 (47.1%) Mean follow up timea (range) 61 (11-113) 81 (28-132) 69.5 (11-132) Resection type (%) Segmentectomy 9 (25.7%) 4 (11.4%) 13 (18.6%) Lobectomy 26 (74.3%) 31 (88.6%) 57 (81.4%)
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