123 Significance of loose tumor cells in pulmonary arteries Table 2. Clinicopathological variables in the two validation cohorts. (continued) Milan OLVG Total Pathological stageb (%) pTis 2 (5.7%) 8 (22.8%) 10 (14.3%) pT1a 7 (20.0%) 6 (17.1%) 13 (18.6%) pT1b 15 (42.9%) 13 (37.1%) 28 (40.0%) pT1c 11 (31.4%) 8 (22.6%) 19 (27.1%) Adenocarcinoma predominant subtype (%) AIS 2 (5.7%) 8 (22.8%) 10 (14.3%) Lepidic predominant 7 (20.0%) 6 (17.1%) 13 (18.6%) Acinar 10 (28.6%) 9 (25.7%) 19 (27.1%) Micropapillary 2 (5.7%) 3 (8.6%) 5 (7.1%) Papillary 3 (8.6%) 1 (2.8%) 4 (5.7%) Solid 11 (31.4%) 8 (22.8%) 19 (27.1%) a months; b according to the TNM 8th edition; AIS, adenocarcinoma in situ Although there were significant differences between the two cohorts with respect to age (Milan mean 67.2, OLVG 61.5, P=.009); gender (Milan 25 male and 10 females, OLVG 12 male and 23 females, P=.002) and follow-up time (Milan mean 61 months, OLVG 81 months, P=.005), the RFS-time in cases with a relapse between the 2 cohorts did not differ (Milan mean 26.7 months [n=7]; OLVG mean 34.9 months [n=8]; P=.49), nor did the dominant tumor type (P=0.66). Therefore, for the analysis of the presence of intravascular cells, the 2 cohorts were combined. Microscopic findings The presence of intravascular cells in the combined cohorts both for invasive and noninvasive (AIS) cases are shown in table 3. Table 3. Presence of intravascular cells (CK7+ and/or macrophages) in both validation cohorts, in invasive and adenocarcinoma in situ (AIS) cases. AIS Invasive Total (%) n=10 n=60 n=70 Intravascular cells CK7+ tumor cells 3 10 13 macrophages 3 6 9 CK7+ and macrophages 2 17 19 Present (total) 8 33 41 (58.6%) Absent 2 27 29 (41.4%) 10
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