159 Elastin in pulmonary pathology Figure 4. A submerged fixed resection specimen with papillary carcinoma. (continued) A, A haematoxylin and eosin (H&E) overview with both peripheral (around rectangle 1) and intrabronchial (around rectangle 2) growth. Note the iatrogenic collapse in peripheral non-malignant lung tissue in the left of rectangle 1. B,C, H&E (B) and elastin (C) staining show details of rectangle 1. Note the presence of elastincontaining remnants of the pre-existing architecture (including vessels and alveolar walls). Rectangle 3 is depicted in (C). D, Higher magnification of elastin staining of rectangle 3. Note the absence of elastin in all of the small papillae. E,F, H&E (E) and elastin (F) staining show details of rectangle 2. The internal control of the elastin staining (around the cartilage; below the bronchial epithelium and vessels) is positive. Rectangle 4 is depicted in (F). G, Higher magnification of elastin staining of rectangle 4. Note the complete absence of elastin intrabronchially, in the small papillae as well as in a slightly larger vessel (lumen with asterisk). 12
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