169 Elastin in pulmonary pathology Statistical analysis Continuous variables are described by mean and standard deviation, categorical variables by frequency and percentage. For each tumor H&E and CK7 data was compared, using the McNemar test. Patients with >1 tumor were in Kaplan-Meier curves categorized as ‘invasive’ if one of the tumors was invasive. Curves were compared using the log-rank test. Statistical analysis was performed in SPSS version 26 (IBM Corp., Armonk, NY, USA). P-values <0.05 were considered statistically significant. Results A total of 74 histological sections of 40 tumors from 33 patients were scored. The clinicopathological characteristics of the patients are presented in table 1. The mean age of the patients was 63.1 ± 10.3. There were 19 females and 14 males. The pathological stage distribution for stage I - IV was 11 10, 10 and 2, respectively. The median follow-up time was 57 months (range 0 - 112). Table 1. Clinicopathological characteristics of the 33 patients n (%) Number of patients 33 Mean age (SD) 63.1 (±10.3) Gender male 14 (42.4% female 19 (57.6%)) Pathological stage 1 11 (33.3%) 2 10 (30.3%) 3 10 (30.3%) 4 2 (6.0% n = number; SD = standard deviation In the first H&E reading 2 out of 21 patients were diagnosed as having a non-invasive adenocarcinoma. In the second H&E reading including iatrogenic collapse an additional 5 patients out of the 21 were diagnosed as non-invasive (Figure 1A). In the CK7 reading the same 7 out of 21 patients were diagnosed as non-invasive, based on a recognizable pattern of pre-existing architecture (Figure 1B). 13
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