194 Chapter 14 Table 3. Clinical variables in both cohorts. Milan OLVG Total p-value Number of patients 35 35 70 Age (years, mean ± SD) 67.2 ± 9.9 61.5 ± 7.6 64.4 ± 9.2 P=.009 Gender (%) P=.002 Male 25 (71.4%) 12 (34.3%) 37 (52.9%) Female 10 (28.6%) 23 (65.7%) 33 (47.1%) Mean follow-up time (months, range) 61 (11-113) 81 (28-132) 69.5 (11-132) P=.005 Resection type (%) Segmentectomy 9 (25.7%) 4 (11.4%) 13 (18.6% P=.128 Lobectomy 26 (74.3%) 31 (88.6%) 57 (81.4%) Note that the cohorts differ with respect to age, gender and follow-up time. According to the initial reports, only one of the cases was diagnosed as AIS. After revision, 9 of originally classified invasive cases were reclassified as AIS. Three were originally classified as acinar with a lepidic component, three as lepidic predominant with an acinar component, one as papillary, one as MIA and one as acinar. Subtyping after revision is shown in Table 4. Table 4. revised subtyping of the adenocarcinomas in both cohorts Adenocarcinoma predominant subtype (%) Milan cases OLVG cases Total (n=70) AIS 2 8 10 (14.3%) Lepidic predominant 7 6 13 (18.6%) Acinar 10 9 19 (27.1%) Micropapillary 2 3 5 (7.1%) Papillary 3 1 4 (5.7%) Solid 11 8 19 (27.1%) Pathologic stage 1) (%) pTis 2 8 10 (14.3%) pT1a 7 6 13 (18.6%) pT1b 15 13 28 (40.0%) pT1c 11 8 19 (27.1%) 1According to 8th edition of UICC/AJCC TNM classification system Survival data The RFS-time in patients with a relapse between the two cohorts did not differ significantly (Milan mean 26.7 months (n=7); OLVG mean 30.0 months (n=7; p=0.77).
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