207 Reproducibility study on invasiveness of pulmonary AdC with a modified classification Results A total of 42 pathologists from 13 countries scored all 70 cases in 2 rounds, before and after a tutorial on iatrogenic collapse. There are 33 pathologists working in academic hospitals and 9 in non-academic hospitals, and they all share a common interest in pulmonary pathology. The median and standard deviation of the experience in pathology is 20 ± 10.6 years (range 4-40 years). Round 1 according to WHO classification Summary data of invasion scoring, measurement of total and invasive size and kappa analysis is shown in Table 1. Table 1. Overview data of 3 rounds: 1st according to the WHO classification, 2nd after tutorial about revised classification and 3rd round repeat revised classification after feedback of the results in the 1st and 2nd rounds including case specific heatmap analysis, underlying histology, biological collapse and recurrence. Round 1 Round 2 Round 3 Number of pathologists N=42 N=42 N=37 Invasion score Total (%) Total (%) Total (%) “No” 291 (9.9%) 516 (17.6%) 342 (15.2%) “Yes” 2572 (87.7%) 2315 (78.7%) 1856 (82.7%) “Not sure” 69 (2.4%) 109 (3.7%) 46 (2.0%) Mean ± SD Mean ± SD Mean ± SD Total tumor size*) 14.9 ± 4.5 mm 14.9 ± 4.6 mm 14.8 ± 4.4 mm Invasive size*) 10.3 ± 5.2 mm 9.1 ± 5.7 mm 9.6 ± 5.4 mm Mean ± SD (range) Mean ± SD (range) Mean ± SD (range) CVtot 6 ± 5% (1-25%) 6 ± 5% (1-29%) ± 5% (1-25%) CVinv Largest, incl “0” 46±45% (2-190%) 71±85% (3-370%) 41± 29% (6-120%) CVinv Largest, excl. “0” 30±22% (2-88%) 36±29% (3-150%) 32±25% (3-110%) CVinv Sum1-3, incl “0” 42±44% (1-180%) 68±88% (1-370%) 33±32% (2-120%) CVinv Sum1-3, excl. “0” 26±22% (1-81%) 32±30 (1-130%) 30±29% (2-110%) Kappa scores Invasion (70 cases, 42 pathologists) 0.27 0.45 0.62 Invasion (41 cases, 36 pathologists) 0.21 0.35 0.56 MIA 0.11 NA NA Pattern Lepidic 0.21 0.34 NA Pattern Papillary 0.21 0.27 NA 15
RkJQdWJsaXNoZXIy MTk4NDMw