212 Chapter 15 being non-invasive in the second round. The mean and standard deviation of invasive size for these 19 cases is in the 1st and 2nd round 15.6 +/- 4.1 and 5.1 +/- 3.0, respectively. For the other 51 cases these were 14.6 +/- 4.6 and 12.2 +/- 4.5, respectively. Most pathologists scored in the 2nd round less invasion then in the 1st round, except for one, who scored all cases ‘invasive’ in both rounds. The kappa score improved from 0.27 to 0.45, including a shift in a selected group of cases towards “no invasion”. The decrease in invasive size essentially happened in the cases reclassified as non-invasive by several pathologists. The distribution of pathologists’ scores for ‘invasion’, ‘no invasion’ or ‘not sure’ is for each case shown in Figure 3B. Table 3. The distribution of invasion scores in 1st (R1) and 2nd round is shown for each case. Invasion round 2 Number of cases Case Invasion R1 “no” “yes” “not sure” p-value 25 80 + yes 42 - 4 77, 29, 34, 15 yes 41 - 2 24, 26 yes 41 1 - 1 68 yes 2 40 - 1 11 yes 2 39 1 - 1 22 no 1 - yes 41 2 7, 25 yes 41 - not sure 1 1 72 no 1 - yes 40 2 10, 16 no 1 - yes 40 not sure 1 1 2 no R1 0 2 - yes 1 2 37 not sure 1 0 1 1 48 yes 2 37 1 - not sure 0 1 0 1 49 yes 3 34 3 - not sure 0 2 0 1 58 yes 4 35 0 - not sure 0 2 1 1 64 no 0 1 0 1,00 yes 1 36 3 not sure 0 1 0 1 31 no 0 2 0 0,69 yes 4 33 1 not sure 1 1 0
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