218 Chapter 15 Figure 5. An example is shown of heatmap analysis in a case with a uniform diagnosis of invasion. In addition, the measurements and variations are discussed as well as the underlying histology. (continued) Case 80. A: case number 1st and 2nd rounds; heatmap, invasion scores 1st and 2nd round and invasion measurements (mean, sd, CV-inv R1 =round1, R2=round 2; B: overlay of invasive lines drawn (orange); C: 6 individual scores and lines denoting invasive area (emphasized in red); D: Boxplot distribution of the pattern scores in 1st (red) and 2nd round (blue); E-P: description of underlying histology in relation to assigned invasive lines and assigned patterns; R: Summary For a mean invasive size smaller than the mean tumor size a round hotspot frequently pointed to a smaller area of invasion. In some of these cases where other pathologists scored ‘no-invasion’, underlying histological details suggest likely criteria being used as indicators of invasion (Figure 6).
RkJQdWJsaXNoZXIy MTk4NDMw