220 Chapter 15 Figure 6. An example is shown of heatmap analysis in case with diagnosis of invasion and non-invasion, where the 1st and 2nd round measurements are provided as well as the underlying histology. The diagnosis is focal invasion (continued) Case 41. A: heatmap, invasion scores and measurements; B: overlay of invasive lines drawn (orange); C: 6 individual scores and lines denoting invasive area (emphasized in red); D: Boxplot distribution of the pattern scores in the 1st (red) and 2nd rounds (blue); E-I: description of underlying histology in relation to assigned invasive lines and assigned patterns; J: Likely invasive area; K: Summary. Examples of overlap in invasive and non-invasive diagnoses and angular shapes of the hot spot, denoting a difference in location and length of the invasive lines, supports a. diagnosis of ‘non-invasion’ (read AIS) (Figure 7).
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