222 Chapter 15 Figure 7. An example is shown of heatmap analysis in case with diagnoses of invasion and noninvasion, where 1st and 2nd round measurements are provided as well as the underlying histology. The diagnosis is no-invasion (read AIS). (continued) Case 45. A: heatmap, invasion scores and measurements; B: overlay of invasive lines drawn (orange); C: 6 individual scores and lines denoting invasive area (emphasized in red); D: heatmap 2nd round and underlying histology; E: Boxplot distribution of the pattern scores in 1st (red) and 2nd round (blue); F-M: description of underlying histology in relation to assigned invasive lines and assigned patterns; N: Summary. Uncertainty about invasion In order to obtain more insight into the invasive assignments the following aspects were examined. Firstly, we investigated the relationship between invasive size and variation in assessment of invasion. The relationship between the invasive size ratio (mean invasive size divided by mean total tumor size) and the mean variation coefficient of invasion (CVinv) per case is in the 1st and 2nd rounds (including invasive size of “0” if a case was scored as non-invasive) shown in Figure 8.
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