223 Reproducibility study on invasiveness of pulmonary AdC with a modified classification Figure 8. The relation between invasive size relative to total tumor size (Ratio mean invasive size / mean total size) and mean variation coefficient of invasive measurement (CV-inv) and mean variation coefficient of total tumor size (CV-tot) for the corresponding case is shown in the 1st and 2nd rounds. A: all scores, including invasive size is “0” if invasion was scored as “No”; B: Only invasive size measurement if invasion was scored as “yes”. Of note, within the assignment of invasion scores an increasing variation is present for smaller invasive sizes, where the corresponding mean variation for total tumor size remains low (<0.2). Moreover, the correlation coefficient in round 1 and 2 is high: -0.95, -0.90, respectively. Whereas the correlation between mean total tumor size and invasion size was 0.07 and 0.14 in the 1st and 2nd rounds, respectively. When the analysis was restricted to scores in “invasion present” cases the correlation coefficients were similar: -0.94 and -0.92. No 15
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