226 Chapter 15 round on a reduced set of cases was approved by most pathologists. The 29 cases with unanimous agreement in round 1 and round 2 were discarded in round 3. The remaining 41 cases were again evaluated for the presence of invasion and location and length of invasive line(s). A summary of the general data is shown in Table 1. The kappa score for round 3 is 0.62. The case-based comparison in the invasion scores in 2nd and 3rd round is summarized in Table 5. Out of the 70 cases 42 (60%) were unanimous invasion “yes” and 1 invasion “no”. In 6 cases a significant change was observed towards invasion “yes” and in one case towards invasion “no”. The distribution of pathologists’ scores for ‘invasion’, ‘no invasion’ or ‘not sure’ in round 3 is for each case shown in Figure 3C. Table 5. Distribution of invasion scores in 2nd and 3rd rounds is shown. Similar scored cases are summarized. The p-value was calculated for a 2X2 table without the ‘not-sure’ category. The discordant scores (false negative) with a recurrence are depicted in red. Number of cases Case ID Invasion round 3 Invasion round 2 “no” “yes” “not sure” p-value* 37 5 yes 36 - 1 24 yes 35 1 - 1 68 yes 2 34 - 1 11 yes 2 33 1 - 1 58 yes 4 31 1 - 1 19 yes 8 26 2 - 1 10 yes 35 - not sure 1 1 2 yes 1 34 - not sure 0 1 1 48 yes 0 33 2 - not sure 1 0 0 1 49 no 0 1 0 1,000 yes 1 31 3 1 31 no 0 1 0,219 yes 5 30 1 26 no 1 0 1 0,250 yes 3 26 3 not sure 2 0 0 1 69 no 2 2 0 1,000 yes 2 24 3 not sure 1 0 2 1 37 no 0 2 0 0,180 yes 7 25 1 not sure 0 1 0
RkJQdWJsaXNoZXIy MTk4NDMw