228 Chapter 15 Table 5. Distribution of invasion scores in 2nd and 3rd rounds is shown. Similar scored cases are summarized. The p-value was calculated for a 2X2 table without the ‘not-sure’ category. The discordant scores (false negative) with a recurrence are depicted in red. (continued) Number of cases Case ID Invasion round 3 Invasion round 2 “no” “yes” “not sure” p-value* 1 21 no 25 3 2 0,625 yes 1 3 0 not sure 0 1 1 1 61 no 24 2 3 1,000 yes 1 3 1 not sure 0 1 1 1 45 no 23 3 4 0,625 yes 1 3 1 not sure 0 1 0 1 53 no 14 9 5 0,146 yes 3 3 0 not sure 0 1 1 1 47 no 21 4 2 0,375 yes 1 5 2 not sure 0 1 0 1 23 no 15 6 5 0,289 yes 2 6 1 not sure 1 0 0 1 6 no 17 0 2 0,008 yes 8 6 1 not sure 0 0 2 1 65 no 15 3 2 0,727 yes 5 8 0 not sure 0 2 1 Clinical relevance Fourteen out of the 70 cases recurred after surgical resection. Nine of the recurrences were recorded in the 25 cases with 100% invasive judgements in round 1 and 2. Cases with a recurrence and a diagnosis of “no invasion” are considered discordant judgements. In the 1st round discordant scores occurred in 3 cases with 1, 1 and 6 judgements, respectively. In the 2nd round this occurred in 4 cases with 2, 3, 5 and 15 judgements, respectively (see also Table 3). In the 3rd round this occurred in 2 cases with 1 and 3 judgements. In the second round >21 pathologists scored “no invasion” in 10 cases, all of which were without a recurrence (mean follow- up time 69.5 months, range 11-132). Survival
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