24 Chapter 2 Figure 1. Histological overview slides: a complete vital tumour, b >50% vital tumour cells (within black lines), c 10-50% vital tumour cells, d <10% vital tumour cells, e no vital tumour cells (i.e. pathologic complete response) Two experienced lung pathologists (JB, ET) independently scored all tumour area slides with respect to the items of amount of viable tumour and distribution of vital tumour cells. There were no discrepancies in their scores. A continuous area of >6 mm tumour in one slide was sufficient for scoring > 10% vital tumour cells. The percentage of vital tumour cells < 10% was defined as small focal areas in one or more sections with an estimated total area of less than 10% of the gross size of the lesion. For the other pathologic items, both pathologists independently evaluated 10 cases, also revealing no discordance. One pathologist (JB) subsequently evaluated the remaining cases. Followup clinical data were retrieved from the patient archives by the relevant clinicians.
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