249 Arguments for pulmonary AIS larger than 7 cm additional cases of large AIS; iv) the radiologic images available in the study were limited in quality due to varying imaging protocols and relative thick slices. Nevertheless, we believe it is unlikely that this leads to misclassification of cases between solid or pneumonia-type tumor morphology. For the two cases with complete histologically examination of the resected lobes the follow-up time is limited. Conclusion Adenocarcinoma in situ > 7cm does exist and can be diagnosed. The restriction of 3 cm size criterion for AIS in the current World Health classification of pulmonary adenocarcinomas may be reconsidered. Sampling in large AIS the whole tumor area for histologic examination is advised. 16
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