25 Outcomes of resected SST after CRT Statistics Statistical analyses were carried out by SPSS for Windows and Mac version 18.0. (IBM, New York, USA). Associations between all histological items, except for those with complete regression in which tumour characteristics were omitted, were tested using the Fisher’s exact test in case of dichotomous variables with a significant level <0.05. Spearman’s correlations were calculated in case of ordinal variables with a significance level of <0.05. Overall survival rates were estimated by Kaplan-Meier curves, and differences between curves were tested by the log-rank test. Where appropriate threshold levels of significance were adjusted for multiple comparisons by the Bonferroni’s correction 36. Results Clinicopathologic characteristics of the 46 patients are shown in Table 2. Most patients were male (74%), almost all were smokers (87%) and the predominant histological subtype was adenocarcinoma (46%). Nineteen cases were staged as stage IIB (41%), 20 as stage IIIA (44%) and 7 as stage IIIB (15%). At the time of diagnosis 9 patients had clinical N2 disease and an additional 2 had N1 disease (table 2). After the induction treatment none of the patients had clinical N2 disease and 4 had N1 disease. Table 2. Characteristics of all eligible patients (n=46) Age (yrs) mean (range) 56.4 (31-78) Gender Male 34 Female 12 Hospital VUmc 27 NKI-AVL 19 Smoking history Pack-years (yrs) mean (range) 30.7 (0-68) Smoker at time of diagnosis Yes 40 No 3 Unknown 3 Smoker at time of treatment Yes 20 2
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