26 Chapter 2 Table 2. Characteristics of all eligible patients (n=46) (continued) No 18 Unknown 8 cTNM (stage) cT3N0M0 (IIB) 19 cT3N1M0 (IIIA) 2 cT3N2M0 (IIIA) 2 cT4N0M0 ((IIIA) 16 cT4N1M0 (IIIA) 0 cT4N2M0 (IIIB) 7 Histology Adenocarcinoma 21 Large cell carcinoma 14 Squamous cell carcinoma 7 Unknown 4a a Treatment based on clinical evidence without pathology diagnosis and without residual tumour in the resection specimen Tumour related histopathologic findings No significant differences were found between the two hospitals for the histologic items, allowing combined data analysis. The resection specimens showed that all lesions were at least 1 cm in size. No vital tumour cells (= pCR) were found in 20 cases (43%). In these 20 specimens, the presumed tumour area showed either necrosis, fibrosis with or without dyselastosis or a combination of the two. Cholesterol clefts were focally or extensively present in the majority of both the pCR and non-pCR cases. All cases showed vascular changes ranging from vasculitis-like changes to complete luminal obliteration and recanalization. The results of the statistical analysis between all scored histological items, are shown in the table 3.
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