39 Prognostic value of MIB-1, PD-L1 and nuclear size in SST after CRT Results The clinicopathological characteristics of the 33 patients are shown in table 1. Most patients were male (n=24, 73%) and adenocarcinoma (AdC) was the most frequent histological type (n= 19, 58%). In 12 cases (36%) less than 10% vital tumour was found. In 27 cases (82%) a N0 lymph node status was diagnosed, whereas in 6 cases (18%) an irradical resection was found (5 R1, 1 R2). The majority of cases were staged as stage IIB (ypT3N0; n=19 [58%]). The median follow-up time was 26 months (range 4-133 months).Gender was not associated with DFS or OS (p=0.27 and p=0.33), nor was age (DFS p=0.99; OS p=0.99) and tumour type (DFS p=0.25; OS p=0.82). A low fraction of vital tumour cells (<10%) showed a tendency for a better prognosis in OS and DFS, but did not reach significance (p=0.062 and p=0.078, respectively). In a subgroup analysis of ypT3N0 stage IIB patients (n=19), the percentage of vital tumour cells made no difference (OS p=0.18; DFS p=0.22). A lower stage (IA/B, versus IIA/B and III/IV) was associated with a better OS (p=0.002), but not with DFS (p=0.13). Free resection margins were associated with a better prognosis: OS and DFS (p<0.001). In the ypT3N0 stage IIB subgroup this difference was also significant. (OS p=0.004; DFS p=0.003). Table 1. Characteristics of all 33 eligible patients in relation to tumour type. Age, mean (range) 55 years (32-73) Follow-up time, median (range) 26 months (4-133) Tumour type Total AdC (n=19) SqCC (n=12) NOS (n=2) 33 Gender Male 13 9 2 24 Female 6 3 0 9 Vital tumour <= 10% 6 5 1 12 >10% 13 7 1 21 N-status N0 17 9 1 27 N1 2 2 1 21 N2 0 1 0 1 R-status R0 15 10 2 27 R1 3 2 0 5 R2 1 0 0 1 3
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