51 Outcomes in Surgically Resected T3N0 NSCLC in the Dutch population Figure 1. Consort flow diagram of NSCLC patients diagnosed in the 4-years period between 20102013, retrieved from the Netherlands Comprehensive Cancer Organisation (IKNL), revealing 809 pT3N0 patients. After exclusion of 114 patients, 683 patients of the 797 patients retrieved after matching to the Nationwide Network and Registry of Histo- and Cytopathology in the Netherlands (PALGA) were analyzed. Statistics We evaluated the prognostic impact of several factors on the overall survival (OS) by using Kaplan-Meier curves and log-rank test. Post-hoc comparisons between the different groups were corrected for multiple testing, using Bonferroni’s correction. Differences in OS between the T3-descriptors were also assessed after correction for age, by using a Cox regression model. A multivariable Cox regression model was built by using a backward selection procedure (p removal = 0.05), to investigate independent prognosticators of OS. The variables included in this backward selection procedure were T3 group, tumor type, residue, type of resection, and postoperative chemotherapy and radiotherapy. The multivariable model was corrected for age (continuous). Associations between pT3N0 and the other variables were tested by the chi-square test. Categorical data was described by means of frequencies and percentages. Statistical analyses were carried out with SPSS for Windows and Mac version 22 (IBM Corp., Armonk, NY, USA). The significance level was set at 0.05. 4
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