52 Chapter 4 Results General From all 36321 registered NSCLC patients in the 4-years period between 2010 through 2013, the data of 683 pT3N0 patients (1.9%) could be analyzed after matching nationwide cancer and pathology databases. Three major pT3N0 subtypes were present: (1) tumor diameter larger than 7 cm (n=251 [37%]), (2) two or more separate tumors in the same lobe (two or more nodules) (n=173 [25%]) and (3) parietal pleural invasion (n=154 [23%]). Tumors with less than a 2-cm margin from the main carina (n=8) were excluded from further analysis because of low numbers and because no cases with atelectasis of the entire lung were found. On the basis of the available pathology report information, no cases with pericardial or mediastinal pleural invasion were encountered. A fourth subtype was recognized. The group with this subtype, termed the mixed subtype, consisted of 105 patients (15%) with a mixture of any combination of the aforementioned three major subtypes major three subtypes: n=105 (15%); ‘mixed’ subtype, mainly, tumor diameter larger than 7 cm and pleural invasion (n=94 [89.5%]). The frequency distribution of the clinicopathological characteristics in relation to the pT3 descriptors is shown in Table 2. Subtype was significantly associated with sex (p < 0.001); there were more men than women with the subtypes, tumor diameter larger than 7 cm, pleural invasion, and mixed subtype, whereas within the subtype two or more nodules, there was an almost equal distribution between men and women. A significant association between subtype and histologic type was found within the subtype two or more nodules, with more adenocarcinomas than squamous cell carcinomas (p < 0.001), as was also the case within the subtypes, tumor diameter larger than 7 cm and pleural invasion, whereas squamous cell carcinoma was seen more frequently within the mixed subtype. Table 2. Frequency distribution of the clinicopathological characteristics for the Four Major pT3N0 Subtypes pT3N0 >7 cm 2nd/multiple nodule(s) Parietal pleural invasion Mixed Total p-value Characteristic n % n % n % n % n (%) All 251 36.7 173 25.3 154 22.5 105 15.4 683 (100) Gender <0.001 male 172 68.5 86 49.7 91 59.1 77 73.3 426 (62.4) female 79 31.5 87 50.3 63 40.9 28 26.7 257 (37.6) Age (years) 0.77 < 60 65 25.9 36 20.8 38 24.7 29 27.6 168 (24.6) 60-69 83 33.1 68 39.3 58 37.7 35 33.3 244 (35.7) ≥ 70 103 41.0 69 39.9 58 37.7 41 39.0 271 (39.7)
RkJQdWJsaXNoZXIy MTk4NDMw