56 Chapter 4 Post-hoc pairwise comparison showed significant differences between most T3 descriptors except between cases with pleural invasion and tumor diameter larger than 7 cm and between cases with pleural invasion and mixed subtypes (Table 3). The difference between subtypes remained significant after correction for age and gender (p<0.001). The backward selection procedure identified T3 subtype, postoperative chemotherapy and age as independent prognosticators of OS (see Table 3). Table 3. Three-year overall survival (OS) with 95% CIs for the pT3 categories and other clinicopathological characteristics. Characteristic 3-yr OS 95% CI p-value HR 95% CI p-value 5-yr OS pT3N0 total 57.0% 49.9% pT3N0 by subtype <0.001 <0.001 >7cm (n=251) 59.9% 53.7% - 66.0% 1.0 Second/multiple nodules (n=173) 70.6% 63.7% - 77.6% 0.6 0.40 - 0.76 62.8% Parietal pleural invasion (n-154) 50.4% 42.4% - 58.5% 1.2 0.88 - 1.5 Mixed (n=105) 37.5% 28.0% - 47.1% 1.7 1.3 - 2.3 28.7% Age 0.004 0.010 <60 64.3% 57.0% - 71.6% 1.02 1.004 - 1.03 60-69 60.6% 54.2% - 66.9% 70+ 49.3% 43.2% - 55.4% Gender 0.001 n.i. Male 52.4% 47.5% - 57.3% Female 64.7% 58.7% - 70.6% Histology 0.006 n.s. AdC (n-321) 64.4% 59.1% - 69.8% SqCC (n=257) 51.9% 45.7% - 58.1% NSCLC-NOS (n=38) 46.4% 30.3% - 62.6% Other 46.5% 34.2% - 58.9% Resection margins 0.007 n.s. Rx 55.4% 49.6% - 61.2% R0 61.7% 56.2% - 67.2% R1 44.2% 32.9% - 55.6% Resection type 0.014 n.s. Lobectomy 59.1% 54.9% - 63.2% Pneumectomy 46.0% 34.7% - 57.3% Bilobectomy 52.2% 38.2% - 66.2%
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