Part III: Collapsed adenocarcinoma in situ; the challenge of defining invasion Chapter 12 Elastin in pulmonary pathology: relevance in tumors with lepidic and/or papillary appearance. A comprehensive understanding from a morphological viewpoint. 147 Chapter 13 Incorporating surgical collapse in the pathological assessment of resected adenocarcinoma in situ of the lung. A proof of principle study. 165 Chapter 14 3-dimensional reflection aids in understanding the fog of 2-dimensional pattern recognition in pulmonary adenocarcinomas. Proposal for a modified classification. 173 Chapter 15 Invasion measurement and adenocarcinoma in situ (AIS) in pulmonary adenocarcinomas of 3 cm or less. A reproducibility study according to the WHO and a modified classification. 201 Chapter 16 Arguments for non-mucinous adenocarcinoma in situ of the lung larger than 7 cm. 235 Chapter 17 General discussion and future perspectives 251 Appendices Supplementary files 276 References 284 Summary 308 Nederlandse samenvatting (Dutch summary) 314 List of publications 320 Dankwoord (Acknowledgements) 326 Curriculum Vitae 329 CRediT authors statements 330
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