93 A Prospective Study of Loose Tissue Fragments in resected NSCLC In conclusion, this prospective study documents that the presence of loose tissue fragments is often a reproducible artifact secondary to mechanical forces caused by specimen handling and grossing, and that it manifests with greater numbers of malignant tumor clusters than benign fragments. These ndings call into question the recent de nition of STAS as a type of lung cancer invasion. 6
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