I 336

Hans Blaauwgeers

Chapter 1 General introduction and outline of the thesis 9
Chapter 2 Complete pathological response is predictive for clinical outcome after tri modality therapy for carcinomas of the superior pulmonary sulcus 19
Chapter 3 The prognostic value of proliferation, PD-L1 and nuclear size in patients with superior sulcus tumours treated with chemoradiotherapy and surgery. 35
Chapter 4 A population-based study of outcomes in surgically resected T3N0 non small cell lung cancer in the Netherlands, defined using TNM-7 and TNM-8; justification of changes and an argument to incorporate histology in the staging algorithm. 47
Chapter 5 Ex vivo artifacts and histopathologic pitfalls in the lung 65
Chapter 6 A prospective study of loose tissue fragments in non-small cell lung cancer resection specimen. An alternative view to “spread through airspaces” 83
Chpater 7 Pulmonary loose tumor tissue fragments and spread through air spaces (STAS): invasive pattern or artifact? A critical review. 95
Chapter 8 To the editor: “Spread through air spaces (STAS) is prognostic in atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma of the lung” 107
Chapter 9 To the editor: “Spread through air spaces (STAS); can an artifact really be excluded?”. 111
Chapter 10 Loose tumor cells in pulmonary arteries of lung adenocarcinoma resection specimen; no correlation with survival, despite high prevalence. 115
Chapter 11 Is Spread Through Air Spaces an in vivo phenomenon or an inducible artifact? 131
Chapter 12 Elastin in pulmonary pathology: relevance in tumors with lepidic and/or papillary appearance. A comprehensive understanding from a morphological viewpoint. 147
Chapter 13 Incorporating surgical collapse in the pathological assessment of resected adenocarcinoma in situ of the lung. A proof of principle study. 165
Chapter 14 3-dimensional reflection aids in understanding the fog of 2-dimensional pattern recognition in pulmonary adenocarcinomas. Proposal for a modified classification. 173
Chapter 15 Invasion measurement and adenocarcinoma in situ (AIS) in pulmonary adenocarcinomas of 3 cm or less. A reproducibility study according to the WHO and a modified classification. 201
Chapter 16 Arguments for non-mucinous adenocarcinoma in situ of the lung larger than 7 cm. 235
Chapter 17 General discussion and future perspectives 251
Supplementary files 276
References 284
Summary 308
Nederlandse samenvatting (Dutch summary) 314
List of publications 320
Dankwoord (Acknowledgements) 326
Curriculum Vitae 329
CRediT Authors statements 330

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