128 Chapter 4 Genetic susceptibility data was available for all 105 patients. Neither homozygous nor heterozygous carrier status of the Bcl-1 polymorphism was associated with neurobehavioral problems in our cohort (Supplemental Table 2). The multivariable model (Table 2) included patient age and sex, maintenance week, SDQ T1 score, maternal age and nationality and parenting stress (NOSI-K delta score). In multivariable analysis, parenting stress (OR 1.16, 95%-CI 1.07-1.26) remained statistically significantly associated with parent-reported neurobehavioral problems. A one-point increase on the NOSI-K delta score (range -125 to 125) gave 16% higher odds of parentreported dexamethasone-induced neurobehavioral problems, corrected for the other included variables. SDQ T1 score also remained statistically significant (OR 0.82, 95%-CI 0.68-0.99), indicating that parents of children who had a higher SDQ score at T1, reported less dexamethasone-induced neurobehavioral problems. Table 2. Multivariable regression models Neurobehavioral problems Sleep problems Odds ratio 95%- confidence interval Odds ratio 95%- confidence interval Age 1.00 0.80-1.26 1.07 0.93-1.24 Sex 1.26 0.32-5.04 0.89 0.28-2.66 Week maintenance 0.99 0.94-1.04 1.02 0.98-1.06 SDQ / SDSC score T11 0.82 0.68-0.99 0.93 0.87-1.00 Parenting stress during dexamethasone2 1.16 1.07-1.26 1.06 1.02-1.10 Nationality mother 0.62 0.05-7.25 0.54 0.10-3.03 Age mother 0.90 0.78-1.04 - - Parental stress T13 - - 1.16 1.02-1.32 Psychological support child - - 0.24 0.05-1.26 Bold values are statistically significant (p<0.05) 1 T1 SDQ and SDSC scores were included for neurobehavioral and sleep problems respectively. 2 Parenting stress during dexamethasone are indicated by the NOSI-K delta score (corrected for the T1 NOSI-K score) 3 Parental stress is indicated by the DT-P total score measured at T1 Abbreviations: DT-P: Distress Thermometer for parents, NOSI-K: Nijmeegse Ouderlijke Stress Index Korte versie, shortened Dutch version of the Parenting Stress Index, SDSC: Sleep Disturbance Scale for Children, SDQ: Strengths and Difficulties Questionnaire
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