Annelienke van Hulst

144 Chapter 4 Supplemental Table 2. Continued No dexamethasone-induced neurobehavioral problems (ΔSDQ<5) Median (IQR) or n (%) Recessive risk allele CC+CG 30 (85.7) GG 5 (14.3) Numbers are depicted as median (interquartile range) or number (%). Bold values are regarded as statistically significant with a p-value <0.20 and were subsequently included in multivariable analyses. Bold underlined values are statistically significant with a p-value <0.05. 1 One patient with BPDCN was excluded from this analysis 2 Patients with CNS involvement (defined as CNS-3 or other CNS manifestations at diagnosis, or TLP+) receive 2 additional intrathecal therapy administrations and are considered as “CNS involvement yes”. MRG patients without CNS involvement receive 13 intrathecal administrations, with CNS involvement 15. 3 Fisher’s Exact test: p=0.019 4 Corrected for score on T1 (correction for two repeated measurements) 5 Fisher’s Exact test (2-sided): p=0.767

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