162 Chapter 5 Table 2. Measurements at two timepoints along with delta scores n T1 T2 Delta p-value Leptin SDS 83 mean (SD) -0.1 (2.1) 1.8 (1.5) 1.9 (1.5) <0.001 Fat mass (kg) median (IQR) 83 5.1 (3.8 ; 8.5) 5.6 (4.3 ; 9.6) 0.7 (0.3 ; 1.1) <0.001 BMI (kg/m2) 89 median (IQR) 17.5 (16.3 ; 19.4) 17.7 (16.5 ; 19.0) 0.1 (-0.2 ; 0.3) 0.112 Hunger score median (IQR) 89 - Average 5 (3 ; 6) 7 (6 ; 8) 2 (1 ; 4) <0.001 - Most 6 (5 ; 7) 8 (7 ; 10) 2 (1 ; 3) <0.001 - Least 2 (0 ; 4) 4 (2 ; 6) 1 (0 ; 3) <0.001 - Fasting (morning) 5 (2 ; 6) 7 (5 ; 9) 2 (1 ; 5) <0.001 Fatigue PedsQL SDS 92 median (IQR) -0.5 (-2.2 ; 0.5) -3.5 (-4.6 ; -2.0) -2.3 (-3.4 ; -0.5) <0.001 Sleep time (SDSC) n (%) 104 - 9-11 hours 80 (77) 53 (51) ≥sleep <0.001 - 8-9 hours 18 (17) 19 (18) 62 (60) - 7-8 hours 2 (2) 13 (13) - 5-7 hours 4 (4) 13 (13) <sleep - <5 hours 0 6 (6) 42 (40) Sleep Score (SDSC) median (IQR) 104 37 (32 ; 46) 48 (38 ; 59) 8 (3 ; 16) <0.001 ≥sleep or <sleep is based on the first question of the SDSC. Abbreviations: SDS: standardized deviation score, SD: standard deviation, n: number, IQR: interquartile range, PedsQL: Pediatric Quality of Life Inventory, SDSC: sleep disturbance scale for children. Correlations between leptin changes and other side effects No significant correlations between delta leptin SDS and changes after five days of dexamethasone in fat mass or the different hunger scores were found (Table 3, Supplemental Figure 2). Furthermore, there was no correlation between delta leptin SDS and delta fatigue and sleep problems (SDSC total score) (Table 3).
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