165 Leptin, hunger and fat 5 Table 4. Descriptive statistics for patients demographics, disease and treatment characteristic; odds ratio (OR) along with 95% confidence interval (95%-CI) estimated from a univariable logistic regression model for high leptin at T1 Normal leptin levels (<1.5 SD) High leptin levels (≥1.5 SD) Median (IQR) or n (%) Median (IQR) or n (%) OR 95%-CI Patient demographics n = 83 n = 21 Age, years 4.8 (4.0-6.5) 12.1 (9.5-15.8) 1.51 1.28-1.77 Sex Boy 48 (58) 15 (71) Girl 35 (42) 6 (29) 0.55 0.19-1.56 Fatigue T1, SDS -0.6 (-2.3-0.6) -0.1 (-0.9-0.2) 1.26 0.90-1.76 SDSC total score T1 36 (32-45) 39 (35-45) 1.00 0.96-1.05 Hunger scores T1 Average 5 (3-5) 5 (4-7) 1.27 0.92-1.74 Most 6 (5-7) 6 (4-7) 1.00 0.76-1.30 Least 2 (0-4) 3 (0-4) 0.99 0.74-1.32 Fasting 5 (2-6) 4 (2-5) 0.93 0.74-1.16 Fat mass T1, kg 4.4 (3.5-5.9) 9.6 (8.2-16.7) 1.19 1.07-1.33 Disease and treatment characteristics Week maintenance 37 (25-49) 27 (19-37) 0.96 0.92-0.99 Asparaginase during study No 74 (89) 19 (91) Yes 9 (11) 2 (9) 0.87 0.17-4.34 CNS involvement1 No 69 (83) 15 (71) Yes 14 (17) 6 (29) 1.97 0.65-5.97 Numbers are depicted ad median (interquartile range) or number (%). Italicized values are statistically significant (p-value <0.05). 1 Patients with CNS involvement defined as CNS-3 or other CNS manifestations at diagnosis, or TLP+) receive 2 additional intrathecal therapy administrations and are considered as “CNSinvolvement yes”. MRG patients without CNS involvement receive 13 intrathecal administrations, with CNS involvement 15. Abbreviations: SDS: standardized deviation score, SDSC: sleep disturbance scale for children, CNS: central nervous system, SD: standard deviation, IQR: interquartile range
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