188 Chapter 6 Day 1 Day 5 Day 1 Day 5 Day 1 Day 5 Day 1 Day 5 Day 1 Day 5 0 5 10 15 20 25 SDQ Total Difficulties score Randomization Cross-over Dexamethasone only RCT Course 1 RCT Course 2 RCT Course 3 RCT Course 4 0 5 10 15 20 25 Delta SDQ Total Difficulties score Randomization Cross-over 20 tal Difficulties score Hydrocortisone Placebo Total Group andomization Cross-over Figure 3. Effect of hydrocortisone and placebo on dexamethasone-induced neurobehavioral problems A) SDQ Total difficulties scores (median with IQR) on day one (start dexamethasone) and day five (stop dexamethasone). Grey triangles represent the total group (n = 51) during the ‘dexamethasone only’ course. During the RCT, patients who receive hydrocortisone or placebo (n = 25 or n = 26) are indicated with orange circles or blue squares, respectively. B) Delta SDQ Total difficulties score (median with IQR) of the total group (n = 51) is indicated in a grey triangle. After randomization patients who receive hydrocortisone or placebo (n = 25 or n = 26) are indicated with an orange circle or a blue square, respectively. Abbreviations: IQR: interquartile range, SDQ: strengths and difficulties questionnaire, RCT: randomized clinical trial
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