Annelienke van Hulst

200 Chapter 6 Supplemental Table 2. Repeated measurement of ΔSDQ in the RCT (T3-T10) Total Difficulties Estimated effect 95% CI Lower bound Upper bound Intervention - Placebo - Hydrocortisone -2.05 -6.00 1.90 Start group - Placebo - Hydrocortisone 0.68 -1.67 3.04 Week of maintenance treatment -0.04 -0.13 0.06 Interaction intervention and week of maintenance treatment - Placebo - Hydrocortisone 0.03 -0.06 0.12 Sex -0.64 -3.02 1.75 Asparaginase 0.66 -3.63 4.95 Age at registration -0.16 -0.50 0.18 Parent who completed questionnaire -0.24 -2.16 1.68 Emotional Problems Estimated effect 95% CI Lower bound Upper bound Intervention - Placebo - Hydrocortisone -0.94 -2.49 0.60 Start group - Placebo - Hydrocortisone 0.79 -0.18 1.75 Week of maintenance treatment 0.003 -0.04 0.04 Interaction intervention and week of maintenance treatment - Placebo - Hydrocortisone 0.01 -0.02 0.05 Sex 0.30 -0.67 1.28 Asparaginase 0.21 -1.54 1.95 Age at registration -0.05 -0.18 0.09 Parent who completed questionnaire -0.02 -0.79 0.75

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