Annelienke van Hulst

206 Chapter 6 Supplemental table 5. Repeated measurement of ΔSDSC in the RCT (T3-T10) Total Score Estimated effect 95% CI Lower bound Upper bound Intervention - Placebo - Hydrocortisone -1.96 -9.27 5.35 Start group - Placebo - Hydrocortisone 5.22 1.58 8.87 Week of maintenance treatment -0.20 -0.36 -0.04 Interaction intervention and week of maintenance treatment - Placebo - Hydrocortisone 0.09 -0.08 0.26 Sex 0.73 -2.96 4.41 Asparaginase -0.68 -7.50 6.13 Age at registration -0.23 -0.74 0.29 Parent who completed questionnaire -2.83 -5.86 0.19 Disorders of initiating and maintaining sleep Estimated effect 95% CI Lower bound Upper bound Intervention - Placebo - Hydrocortisone 0.12 -4.20 4.44 Start group - Placebo - Hydrocortisone 2.66 0.56 4.75 Week of maintenance treatment -0.08 -0.17 0.01 Interaction intervention and week of maintenance treatment - Placebo - Hydrocortisone 0.02 -0.08 0.12 Sex 0.46 -1.66 2.57 Asparaginase 1.78 -2.14 5.70 Age at registration -0.01 -0.30 0.29 Parent who completed questionnaire -1.31 -3.06 0.45

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