Annelienke van Hulst

212 Chapter 6 Supplemental table 7. Repeated measurement of Δ Pediatric Quality of Life questionnaire (PedsQL) in the RCT (T3-T10) Total Score Estimated effect 95% CI Lower bound Upper bound Intervention - Placebo - Hydrocortisone 3.25 -13.69 20.20 Start group - Placebo - Hydrocortisone -2.80 -9.30 3.70 Week of maintenance treatment 0.14 -0.16 0.45 Interaction intervention and week of maintenance treatment - Placebo - Hydrocortisone -0.06 -0.44 0.33 Sex -1.62 -8.11 4.88 Asparaginase 4.54 -7.68 16.76 Age at registration 0.10 -0.93 1.12 Parent who completed questionnaire 2.75 -3.08 8.58 Physical functioning Estimated effect 95% CI Lower bound Upper bound Intervention - Placebo - Hydrocortisone 14.28 -6.77 35.34 Start group - Placebo - Hydrocortisone -3.08 -12.86 6.71 Week of maintenance treatment 0.17 -0.26 0.59 Interaction intervention and week of maintenance treatment - Placebo - Hydrocortisone -0.23 -0.71 0.25 Sex -0.84 -10.69 9.00 Asparaginase 3.16 -15.07 21.39 Age at registration -0.75 -0.81 2.31 Parent who completed questionnaire 6.25 -2.02 14.52

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