239 The role of the MR 7 Supplemental Figure 3. (A), Cell toxicity screening of doxycycline-induced RehNR3C1 (upper panels) and RehNR3C2 (lower panels) with and without 20µM spironolactone (MR antagonist) treatment in combination with prednisolone, dexamethasone or hydrocortisone. Spironolactone treatment in RehNR3C2 cells reversed the acquired steroid sensitivity. (B), Cell toxicity screening of doxycycline-induced RehNR3C1 (upper panels) and RehNR3C2 (lower panels) with and without 4µM eplerenone (MR antagonist) treatment in combination with prednisolone, dexamethasone or hydrocortisone. Eplerenone treatment in RehNR3C2 cells reversed the acquired steroid sensitivity.
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