244 Chapter 7 Supplemental Table 3. Continued NCI risk group NCI standard risk 71 (54.2) NCI high risk 60 (45.8) Prednisone response day 8 Good 114 (87) Poor 14 (10.7) Unknown 3 (2.3) Risk group stratification SR 24 (18.3) MR 95 (72.5) HR 12 (9.2) MRD day 33 Negative 30 (22.9) Positive 97 (74) Not done 4 (3.1) MRD day 79 Negative 80 (61.1) Positive 45 (34.4) Not done 6 (4.6) GR (NR3C1) expression Median (range) 199.6 (41.9-567.1) Low 65 (49.6) High 66 (50.4) MR (NR3C2) expression Median (range) 5.4 (0.2-122.3) Low 65 (49.6) High 66 (50.4) Abbreviations: n: number, ALL: acute lymphoblastic leukemia, CNS: central nervous system, NCI: National Cancer Institute, SR: standard risk, MR: medium risk, HR: high risk, MRD: minimal residual disease, GR: glucocorticoid receptor, MR: mineralocorticoid receptor Supplemental Table 4. Estimated hazard ratio with 95%-CI for any first event Hazard ratio 95%-CI Lower bound Upper bound Age at diagnosis years 1-4 5-9 0.38 0.11 1.28 10-14 0.93 0.33 2.63 15-18 0.63 0.14 2.85 Sex Girl Boy 0.86 0.37 1.99 ALL subclass B-cell ALL T-cell ALL 2.17 0.72 6.53
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