252 Chapter 8 Table 1. Continued Chapter Short title Purpose Sample 6 Hydrocortisone as an intervention To validate the finding that hydrocortisone addition to dexamethasone treatment reduces clinically relevant dexamethasone-induced neurobehavioral problems n = 52 pediatric ALL patients with clinically relevant dexamethasoneinduced neurobehavioral problems 7 The role of MR in steroid cytotoxicity To evaluate the role of the mineralocorticoid receptor (MR) in steroid-induced cytotyoxicity - Doxycycline-inducible Reh cell lines (with MR or GR) - 1 ALL PDX model, 2 primary ALL patient samples (all ETV6RUNX1) - n = 278 pediatric ALL patients Abbreviations: ALL: acute lymphoblastic leukemia, BMI: body mass index, DT-P: distress thermometer for parents, GR: glucocorticoid receptor, MR: mineralocorticoid receptor, NOSI-K: Nijmeegse Ouderlijke Stress Index Korte versie, adapted from the Parenting Stress Index, PedsQL(- MFS): Pediatric Quality of Life Pediatric Quality of Life Inventory (– Multidimensional Fatigue Scale),
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