277 English summary A The research and implications for clinical care described in this thesis are an essential step towards beating dexamethasone-induced side effects. We implemented the innovative strategy to offer parents and patients the choice between open-label placebo or hydrocortisone in a shared decision making setting whenever clinically relevant dexamethasone-induced neurobehavioral problems occur. Furthermore, we attempt to downscale the nocebo-effect of dexamethasone, by creating awareness, adjusting dexamethasone information, and training healthcare providers to discuss dexamethasoneinduced side effects in a uniformly prepared, concise, less repeated and more neutral way. We do not expect all the side effects of dexamethasone to suddenly disappear, but if the edges are taken off, a step towards enhanced quality of life for both patients and their families is achieved during the 2 years of ALL treatment.
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