38 Chapter 2 Table 1. Results per Adverse Psychological Reaction (APR) study Study Study design A priori design for risk factors N= n= APR outcome Age Steroid APR outcome Bostrom et al (2003)37 RCT No 1060 6 1-10 years Dex (6 mg/ m2/d) Pred (40 mg/m2/d) Neuropsychiatric toxicities Domenech et al (2014)38 RCT No 1947 53 0-18 years Dex (6 mg/ m2/d) Pred (60 mg/m2/d) Personality change Drigan et al (1992)48 Prospective Yes 38 38 SR: 51.4 months (29-94) HR: 49.1 months (25-63) Pred (40 mg/m2/d or 120 mg/ m2/d) Behavior changes Eipel et al (2013)40 Retrospective No 346 29 1-18 years Dex (10 mg/ m2/d) Pred (60 mg/m2/d) Seriously altered behavior or steroid psychosis Eipel et al (2016)39 Retrospective No 346 29 0,2-17,9 years (median 4.95) Dex (10 mg/ m2/d) Pred (60 mg/m2/d) Seriously altered behavior or steroid psychosis Eiser et al (2006)51 RCT Yes 45 41 7,2 (3.8 SD) years Dex Pred Child difficulties FelderPuig et al (2007)4 Prospective Yes 37 20 9,27 (3,96 SD) years Dex (10 mg/ m2/d) Pred (60 mg/m2/d) Adverse psychological reactions
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