40 Chapter 2 Table 1. Continued Study Study design A priori design for risk factors N= n= APR outcome Age Steroid APR outcome Harris et al (1986)41 Prospective No 16 16 4-16 years Pred (60 mg/m2/d) Behavior Hough et al (2016)42 RCT No 3126 18 1-25 years (median 5 years) Dex (6 or 10 mg/m2/d) Steroid induced psychosis Igarashi et al (2005)43 RCT No 359 3 1-10 years Pred (40-60 mg/m2/d) Dex (6-8 mg/m2/d) Neuropsychiatric adverse event Kaymak Cihan et al (2017)44 Retrospective No 49 13 1.4-17 years Pred (40-60 mg/m2/d) Dex (10 mg/ m2/d) Depression symptoms (according to CTCAE 4.0) Marino et al (2009)45 Retrospective No 36 25 5,3 (1,316) years Dex (10 mg/ m2/d) Pred (60 mg/m2/d) Neuropsychiatric signs Messina et al (1989)49 Prospective No 26 23 8 (3-16) years Pred (60 mg/day) Mood, activity level and behavior Mitchell et al (2005)46 RCT No 1603 58 1-18 years Pred (40 mg/m2/d) Dex (6,5 mg/ m2/d) Acute behavioral toxicity (grade III/IV) Mrakotsky et al (2011)25 Prospective repeated measures Yes 60 60 2-17 years Pred (40 mg/m2/d) Dex (6 mg/ m2/d) Neurobehavioral problems
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