42 Chapter 2 Table 1. Continued Study Study design A priori design for risk factors N= n= APR outcome Age Steroid APR outcome Pound et al (2012)52 Prospective Yes 43 43 7 (SD 4.1) years Pred Dex Behavioral problems Warris et al (2016)9 RCT No 46 46 3-16 years Dex (6 mg/ m2/d) Behavior Warris et al (2016)53 RCT Yes 46 46 6,0 (4.09.8) years Dex (6 mg/m2/ day) Behavior Yetgin et al (2003)47 RCT No 205 3 5,5 years (11 months-16 years) Pred (60mg/m2/ day) HDMP (600900mg/m2/ day) Behavioral disturbance Note: Age reported as mean or range. Color-coding: red (lower quality), orange (medium quality), green (higher quality). Abbreviations: ABCB1: ATP-Binding Cassette B1, ACTH: Adrenocorticotropic Hormone, APR: Adverse Psychological Reaction, ASO: allele-specific oligonucleotide, AUC: Area Under the Curve, CBCL: Child Behavior Checklist, CDI: Children’s Depression Inventory, CI: Confidence Interval, CLIA: Chemiluminescence-based Immunoassay, CSF: Cerebrospinal Fluid, CTCAE: Common Terminology Criteria for Adverse Events, Dex: Dexamethasone, DST: Dexamethasone Suppression Test,
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