43 Risk factors: a systematic review 2 Measurement outcome Risk factor Measurement risk factor Results Risk of bias: QUIPS domains CBCL - Type of steroid - Age (<5, >5) - Sex - Assigned by protocol - Patient record - Patient record Dex: ≤5 years no difference >5 years: more total (p=.041), affective (p=.015) and anxiety problems (p=.050) Age: ≤5 years: higher internalizing (p=.003), externalizing (p=.005) and total problems (p=.003). >5 years: higher externalizing (p=.021), aggressive behavior (p=.017) and oppositional defiant problems (p=.036) Sex: NS 0/6 high SDQ Age Patient record No relation between age and dex induced behavior problems 1/6 high SDQ - Cortisol - Dex PK - DST, CLIA - Trough levels Cortisol: Baseline and AUC not correlated with behavior. Cortisol suppression correlated with SDQ conduct and impact score. Trough levels: no correlation with behavior 2/6 high Unknown Type and dose of steroid Per protocol HDMP: 3 behavioral disturbances, Pred: 0. NS 4/6 high GST: glutathione and glutathione-S-transferase, HDMP: High Dose Methylprednisolone, HR: High Risk, IL-10: interleukin-10, NS: Not Significant, MAO: monoamine oxidase, OR: Odds Ratio, PCR: Polymerase Chain Reaction, PK: Pharmacokinetics, Pred: Prednisone, RCT: Randomized Controlled Trial, RFLP: restriction fragment length polymorphism, RR: Relative Risk, SAE: Serious Adverse Event, SD: Standard Deviation, SDQ: Strength and Difficulties Questionnaire, SNP: Single Nucleotide Polymorphism, SR: Standard Risk, WHO: World Health Organization.
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