50 Chapter 2 Table 3. GRADE Adverse Psychological Reactions Potential Risk Factors Univariable Multivariable Number of patients Number of studies Number of cohorts + 0 - + 0 - Age (younger age) 331 9 9 325,41,52 59,40,46,48,49 142 - - - Sex (boys) 191 5 5 0 440,46,49,52 148 - - - Type of steroid (Dex) 284 8 8 246,52 64,25,37,38,43,51 0 - - - Steroid dose (higher) 124 4 4 148 325,47,49 0 - - - Cumulative steroid dose (higher) 60 1 1 0 125 0 - - - Parental coping strategy 0 0 0 - - - - - - Parental stress 0 0 0 - - - - - - History of psychiatric problems 0 0 0 - - - - - - Genetic predisposition N363S 87 5 4 0 54,39,40,44,45 0 - - - Bcl1 67 4 4 144 34,39,45 0 - - - ER22/23EK 67 3 3 0 34,39,45 0 - - - ABCB1 gene 25 1 1 0 145 0 - - - GST gene 25 1 1 0 145 0 - - - IL-10 gene 25 1 1 0 145 0 - - - Platelet MAO activity (higher) 23 1 1 149 0 0 - - - Cortisol levels (higher) 66 2 2 0 24,53 0 - - - ACTH level (higher) 20 1 1 0 14 0 - - - Dex kinetics 46 1 1 0 153 0 - - - Neuronal cell destruction 20 1 1 0 14 0 - - - Notes: Phase= phase of investigation. For uni- and multivariable analyses: += number of significant effects with a positive value; 0= number of non-significant effects; -= number of significant effects with a negative value. Below the reference for each study is depicted. For GRADE factors: √= no serious limitations; x= serious limitations (or not present for moderate/large effect size, dose effect); unclear= unable to rate item based on available information. For overall quality of evidence: += very low; ++= low, +++= moderate, ++++= high.
RkJQdWJsaXNoZXIy MTk4NDMw