51 Risk factors: a systematic review 2 GRADE Factors36 Phase Study limitations Inconsistency Indirectness Imprecision Publication bias Moderate/large effect sizes Dose effect Overall quality 1,2 x x √ unclear x unclear x + 1,2 x √ √ unclear x unclear NA + 1,2 √ x √ unclear √ unclear unclear + 1,2 x √ √ unclear x unclear unclear + 2 √ NA √ √ x unclear unclear ++ NA NA NA NA NA NA NA NA None existing NA NA NA NA NA NA NA NA None existing NA NA NA NA NA NA NA NA None existing 1,2 x √ √ unclear √ unclear NA + 1,2 x x √ unclear √ unclear NA + 1,2 x √ √ unclear √ unclear NA + 1 x NA √ unclear x unclear NA + 1 x NA √ unclear x unclear NA + 1 x NA √ unclear x unclear NA + 1 x NA √ unclear x unclear x + 2 x √ √ x x unclear x + 2 x NA √ x x unclear x + 2 √ NA √ unclear x unclear unclear + 2 x NA √ unclear x unclear x + Abbreviations: ABCB1: ATP-Binding Cassette B1, ACTH: Adrenocorticotropic Hormone, Dex: Dexamethasone, GRADE: Grading of Recommendations Assessment, Development and Evaluation GST: glutathione and glutathione-S-transferase, IL-10: interleukin-10, MAO: Monoamine Oxidase, NA: not applicable
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