52 Chapter 2 Table 4. GRADE Sleep problems Potential Risk Factors Univariable Multivariable Number of patients Number of studies Number of cohorts + 0 - + 0 - Age (younger age) 208 3 2 0 248,54 113 0 0 0 Sex (girls) 208 4 2 213,48 154 113 0 0 155 Type of steroid (Dex) 61 1 1 - - - 112 0 0 Steroid dose (higher) 208 4 2 313,54,56 148 0 - - - Parental coping strategy 0 0 0 - - - - - - Parental stress 0 0 0 - - - - - - History of sleep problems 0 0 0 - - - - - - Genetic predisposition AHSG 88 1 1 156 0 0 - - - IL-6 (G174C) 88 1 1 0 156 0 - - - IL-6 (C634G) 88 1 1 0 156 0 - - - Dex kinetics 134 2 2 156 153 0 0 156 0 Albumin level (higher) 88 1 1 0 156 0 - - - Notes: Phase= phase of investigation. For uni- and multivariable analyses: + = number of significant effects with a positive value; 0= number of non-significant effects; - = number of significant effects with a negative value. Below the reference for each study is depicted. For GRADE factors: √= no serious limitations; x= serious limitations (or not present for moderate/large effect size, dose effect); unclear = unable to rate item based on available information. For overall quality of evidence: + = very low; ++ = low, +++ = moderate, ++++ = high.
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