53 Risk factors: a systematic review 2 Grade Factors36 Phase Study limitations Inconsistency Indirectness Imprecision Publication bias Moderate/large effect sizes Dose effect Overall quality 1,2 x x √ unclear x unclear unclear + 1,2,3 √ x √ unclear x unclear NA ++ 2 √ NA √ √ x unclear unclear ++ 1,2 √ √ x √ x unclear x + NA NA NA NA NA NA NA NA None existing NA NA NA NA NA NA NA NA None existing NA NA NA NA NA NA NA NA None existing 2 √ NA √ unclear x unclear NA + 2 √ NA √ unclear x unclear NA + 2 √ NA √ unclear x unclear NA + 2 √ √ √ unclear x unclear x ++ 2 √ NA √ unclear x unclear x + Abbreviations: AHSG: α2-Heremans-Schmid glycoprotein, Dex: Dexamethasone, GRADE: Grading of Recommendations Assessment, Development and Evaluation, IL-6: interleukin-6, NA: not applicable.
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