65 Risk factors: a systematic review 2 SUPPLEMENTAL TABLES Supplemental Table 1. Patient, Intervention, Comparison and Outcome (PICO) Patient population Children (0-18 years old) with acute lymphoblastic leukemia receiving glucocorticoid treatment Intervention Comparison Sociodemographic factors Young childhood age Older childhood age Girl Boy Treatment factors Dexamethasone Prednisone High dose steroid Low dose steroid Parental factors Unhealthy parental coping strategy Healthy parental coping strategy Parental stress No parental stress Medical history History of APR / sleep problem No history of APR / sleep problem Genetic predisposition SNP present SNP absent Outcome Adverse psychological reaction and/or Sleep problem Abbreviations: APR: Adverse Psychological Reaction, SNP: Single Nucleotide Polymorphism
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