CONTENT Chapter 1 General introduction 9 Chapter 2 Risk factors for steroid-induced adverse psychological reactions and sleep problems in pediatric acute lymphoblastic leukemia: A systematic review Psycho-Oncology. 2021 Jul;30(7):1009-1028 29 Chapter 3 Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design BioMed Central Pediatrics. 2021 Sep;21(1):427-435 97 Chapter 4 Unraveling Dexamethasone-Induced Neurobehavioral and Sleep Problems in Children With ALL: Which Determinants Are Important? Journal of Clinical Oncology – Precision Oncology. 2023 Jun;7 :e2200678 117 Chapter 5 Leptin increase during dexamethasone and its association with hunger and fat, in pediatric acute lymphoblastic leukemia Under review 153 Chapter 6 Hydrocortisone to reduce dexamethasone-induced neurobehavioral side-effects in children with acute lymphoblastic leukemia-results of a double-blind, randomized controlled trial with cross-over design European Journal of Cancer. 2023 Apr;187:124-133 177 Chapter 7 The role of the mineralocorticoid receptor in steroid-induced cytotoxicity in pediatric acute lymphoblastic leukemia Under review 221 Chapter 8 General discussion and future perspectives 247 Addendum English summary 273 Nederlandse samenvatting 279 About the author 285 List of publications 289 PhD portfolio 295 Dankwoord 301
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