78 Chapter 2 Supplemental Table 5. Studies on the influence of genetic variation on steroid induced adverse psychological reactions Study population Analyses Method Cohort size (cases / control) Country of origin; ethnicity Sex (% males) Steroid treatment Replication Definition endpoint Eipel et al. (2013)40 Candidate gene 346 (29/317) Hungary (ethnicity not specified) 57 Pred 60mg/m2 and dex 10mg/m2 No Seriously altered behavior or steroid psychosis Eipel et al (2016)39 Candidate gene 346 (29/317) Hungary (ethnicity not specified) 60 Pred 60mg/m2 and dex 10mg/m2 No Seriously altered behavior or steroid psychosis 257 (33/224) 54 FelderPuig et al. (2007)4 Candidate gene 37 (20/17) Austria (ethnicity not specified) 59.5 Pred 60mg/m2 and dex 10mg/m2 No Steroid induced APR measured with CBCL questionnaire Kaymak Cihan et al. (2017)44 Candidate gene 47 (13/34) Turkey (ethnicity not specified) 47.8 Pred (4060 mg/ m2/d) Dex (10 mg/ m2/d) No Depression symptoms (according to CTCAE 4.0) Marino et al. (2009)45 Candidate gene 36 (25/11) Italy (ethnicity not specified) 47.2 Pred (60mg/ m2/d) Dex (10mg/ m2/d) No Neuropsychiatric signs Abbreviations: APR: adverse psychological reaction, ABCB1: ATP-Binding Cassette B1, CBCL: Child Behavior Checklist, CTCAE: Common Terminology Criteria for Adverse Events, dex: dexamethasone, GR: glucocorticoid receptor,
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