79 Risk factors: a systematic review 2 Studied no of SNPs (adj for multiple testing) Gene/ region Variant Effect allele / genotype MVA adjust for: OR P-value 1 (no multiple testing) NR3C1 (GR gene) N363S (rs6195) Carrier vs noncarrier None 0.7 (0.163.13) 1.0 3 (no multiple testing) NR3C1 (GR gene) N363S (rs6195) Carrier vs noncarrier None 0.7 (0.163.13) 1.0 ER22/23EK (rs6189/rs6190) Carrier vs noncarrier None NA 0.695 Bcl-1 (rs41423247) CC vs GC+GG, GG vs CC+GC None NA 0.785 0.209 3 (no multiple testing) NR3C1 (GR gene) N363S (rs6195) Not stated None NA n.s. ER22/23EK (rs6189/rs6190) Not stated None NA n.s. Bcl-1 (rs41423247) Not stated None NA n.s. 2 (no multiple testing) NR3C1 (GR gene) N363S (rs6195) NA NA NA NA Bcl-1 (rs41423247) CC vs CG CC vs CG+GG None 7.5 5.2 0.011 0.04 8 (no multiple testing) NR3C1 (GR gene) Bcl-1 (rs41423247) Mutation vs wild type None NA n.s. N363S (rs6195) ER22/23EK (rs6189/rs6190) ABCB1 T-129C G2677T C3435T GST-P1 A2627G IL-10 A1082G GST: glutathione and glutathione-S-transferase, IL-10: interleukin-10, MVA: multivariable analysis, NA: not applicable, n.s.: not significant, OR: odds ratio, PCR: polymerase chain reaction, pred: prednisone, SNP: single nucleotide polymorphism
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