Annelienke van Hulst

Chapter 1 General introduction 9
Chapter 2 Risk factors for steroid-induced adverse psychological reactions and sleep problems in pediatric acute lymphoblastic leukemia: A systematic review 29
Chapter 3 Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design 97
Chapter 4 Unraveling Dexamethasone-Induced Neurobehavioral and Sleep Problems in Children With ALL: Which Determinants Are Important? 117
Chapter 5 Leptin increase during dexamethasone and its association with hunger and fat, in pediatric acute lymphoblastic leukemia Under review 153
Chapter 6 Hydrocortisone to reduce dexamethasone-induced neurobehavioral side-effects in children with acute lymphoblastic leukemia-results of a double-blind, randomized controlled trial with cross-over design 177
Chapter 7 The role of the mineralocorticoid receptor in steroid-induced cytotoxicity in pediatric acute lymphoblastic leukemia Under review 221
Chapter 8 General discussion and future perspectives 247
English summary 273
Nederlandse samenvatting 279
About the author 285
List of publications 289
PhD portfolio 295
Dankwoord 301

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