113 Redundant tooth loss prior to head and neck radiotherapy 5 Results One thousand six hundred and sixteen patients were seen for dental assessment prior to RT of whom 1258 were excluded (Figure 2). In total, 358 patients were included, 249 males (69.6%) and 109 females (30.4%). The mean age was 63.6 years (SD 11.3). Baseline characteristics are presented in Table 1. A total of 1759 teeth were removed from these 358 patients. Of these 1759 teeth, 1274 teeth (74%) appeared to have been removed redundantly, based on the Dmean of <40Gy. Using the Dmax of <40Gy, 1080 teeth (61%) appeared to have been removed redundantly (Table 2). 501 patients 358 patients 398 patients Excluded: Unknown primary tumor (n=11) Centrally located tumor (n=14) Bilateral proven tumor spread (n=15) Excluded: previous head and neck RT (n=78) protontherapy (n=9) brachytherapy (n=2) RT with palliative intent (n=13) early termination of RT (n=1) Excluded: edentulous (n=635) no tooth extractions pre-RT (n=376) tooth extraction after RT(n=1) neglected remaining dentition (n=97) lost teeth incl. in jawresection (n=6) 1616 patients Figure 2 - Exclusion criteria. Of the potential factors contributing to teeth receiving a cumulative RT dose ≥40Gy, tumor location and N-classification emerged as the most important factors in the multivariable regression analysis (Figure 3). Logistic regression outcomes for each factor per individual tooth in Figure 3 can be found in Supplementary Table 1.
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